Moreover, only patients with tumors that expressed wild-type K-rasresponded to cetuximab_an objective response was recorded in 31 of 48 (64.6%) patients with wild-type K-rastumor status but in none of the 30 patients with K-rasmutations ( P < 0.0001 diagnostic accuracy of K-ras mutation status = 78.2%). Twenty-nine of 65 (44.6%) patients with EGFR mRNA overexpression responded to cetuximab, while only two patients (2/13, 15.4%) without EGFR mRNA overexpression of responded to cetuximab ( P = 0.049, diagnostic accuracy of EGFR mRNA = 51.3%). Results: Of 78 mCRC patients, K-rasmutations were identified in 30 (38.5%) cases, and EGFR mRNA overexpression were observed in 65 patients (83.3%). Materials and Methods: We retrospectively analyzed 78 mCRC patients receiving cetuximab plus the FOLFIRI or FOLFOX-4 chemotherapy with regard to the correlation between response rate and progression-free survival rate (PFS) as well as K-ras mutation status/EGFR mRNA expression using direct sequencing and membrane-array, respectively. ![]() K-ras mutation status and epidermal growth factor receptor (EGFR) have been suggested to be candidate markers for predicting survival of these patients. #Typestatus plus plusįive WPeMatico add-ons included in this WPeMatico PLUS membership at more than 35% off the original value!Įarn more than 35% discount by purchase of the PLUS membership with all these more wanted features for autoblogging with WordPress in a very easy professional way.Ĭurrently are 5 Add-Ons plus the Free core to perform the WPeMatico PLUS membership.Background: The combinations of cetuximab with irinotecan-based or oxaliplatin-based chemotherapy for the first-line treatment of mCRC (metastatic colorectal cancer) have been proven to be promisingly efficient however, the response rate is variable and markers predictive of response are urgently required. See some details below and find more data in each product page. Campaigns Feeds and options are organized into campaigns.Comfortable interface like Worpress posts editing for every campaign.Integrated with the Simplepie library that comes with WordPress.This includes RSS 0.91 and RSS 1.0 formats, the popular RSS 2.0 format, Atom… Feed auto discovery allows you to add feeds without even knowing the exact URL.For maximum performance, you can make the RSS fetching process be called by an external cron job, or simply let WordPress handle it.Options to set max items per fetch, comments on or off, sets authors and a lot of more options.It allows to publish to any public WordPress Custom post type, status and post formats.Images caching are integrated with WordPress Media Library.The first image attached to a post can be marked as the Featured Image.It is possible to upload & attach only the featured image ignoring the others.You can choose whether to upload images as post attachments or not.Define custom links for the words or phrases you specify.Īlso upload remote images or link to source. Detailed Log sending to custom e-mail.Define custom words to search into content or title to assign every post to specified category. Option to choose what roles can see the dashboard widget.Dashboard Widget with campaigns summary.Option to replace title links (s) to point to the source site.On every executed cron or only on errors with a campaign. With lots of amazing and premium features to work with images and content parsers/filters, performs custom excerpts, tags and allows you make your own custom feeds. Professional Add-on :Įxtends WPeMatico with a lot of advanced functions and a lot of new features to parse and filter feed items contents, filters for featured, media, enclosure and in-content images, automatic tags generation, inserts custom fields with every post and much more. Take a look to all its features by clicking here.Takes the title and and scratches its web page to find the full content with option to search for multi-page articles. Set the featured image from meta tags of source web page, Open Graph or Twitter images. Works automatically with 95% of the websites, but if not, allows set up a configuration file for every domain pointing to what section of the web page must be obtained. Includes a config file editor to add support for custom domains that moves all the config files to a local folder to don’t overwrite the files when updates the plugin.
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